Oh ugh, that question from my mother would drive me up the wall. Most of it is because whenever I feel bad, she manages to make it all about her or co-opts my anxiety or something, and then I end up having to soothe her. Also, she puts a lot of pressure on me to confide in her so we can have valued mother-daughter emotional closeness, and if I do, she offers advice that is frequently anger-making. It also feels like a very loaded question, because there's an underlying sense that she wants me to say yes (as opposed to a more neutral question like "How's stuff going?" or "How are you feeling?"). I have no idea if your mother does anything even remotely similar, but just wanted to say that I don't think you getting irritated at that question is weird at all!